PROJECT DESCRIPTION
The R.I. x A.A project stems from a sharing of common research objectives identified by the partnership formed between several Members, companies, and research organizations of the Ribes-Nest network. Through the research activities to be carried out, it intends to study the aging of the Italian population, which, as for almost all European countries, represents one of the most important challenges for public health and the world of work, requiring ever-increasing economic costs and leading to serious problems in all areas of social coexistence. Faced with this scenario, the development of new tools aimed at monitoring quality of life and improving aging conditions (“
active ageing”) becomes crucial.
To address this issue concretely, it is appropriate to investigate crucial aspects such as understanding the biology of aging, the various predictive and functional factors related to multimorbidity, the life course trajectories of active and healthy aging, and the sphere related to care and assistance.
The R.I. x A.A. project is divided into 4 work packages (WP):
1. Innovative applications and development of new methodologies and systems usable for the assessment of cognitive decline and aging performance; 2. Technological systems, processes, and instrumentation serving the monitoring and improvement in the different stages of aging and various related pathologies; 3. Selection of models and tests to evaluate the different conditions of active aging that hinder quality of life; 4. Development of innovative processes and/or products usable to optimize living conditions and changes during the aging phase.
The impact and expected results largely fall within the Smart Health trajectories identified in the regional call dedicated to RIRs, and approved by the Veneto Region with DGR No. 729 of June 26, 2024, covering the interests of companies in the Health and Well-being sector, including the biotechnology, MedTech, and Pharma segments.
EXPECTED RESULTS
- Biological indicators of aging will be identified to develop personalized diagnostic kits, useful for monitoring health status in a timely and non-invasive manner, allowing for tailored interventions and reducing the need for frequent clinical visits.
- The process of autophagy in relation to Parkinson’s Disease on a genetic basis will be explored in depth, bringing original results thanks to the joint expertise of companies and research organizations.
- Interventions on metabolism capable of activating autophagy will be evaluated, in order to define protocols useful for improving metabolic conditions in the elderly.
- Development of models to study oxidative stress and its role in degenerative retinal pathologies. The work aims to provide solutions to counter vision loss, a condition with high social and economic impact.
- Tests on stem cell-derived macrophages could lead to the identification of new inflammatory markers and the exploration of the clinical potential of synthetic peptides, with applications ranging from regenerative medicine to cosmetics.
- New bioactive compounds will be developed for the treatment of specific pathologies, with possibilities for industrialization, especially in the ophthalmological and rare disease sectors.
- Innovative technologies such as QMR and new supplements based on bioactives and prebiotics (e.g., GOS from whey) will be evaluated for their effectiveness in slowing down osteoarticular degenerative processes and supporting the immune system, contributing to well-being in old age.
Lead Partner: RIBES for the Health Ecosystem and Smart Food
Project Partners: + Watt, Bmr-Genomics, Clonit, Dwb Proteins, Fidia Farmaceutici, Fresenius Kabi Ipsum, Microbion, Micromed, Oxilab, Telea Electronic Engineering, University of Padua, University of Verona, Ca’ Foscari University of Venice, National Research Council (IN)